The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.

@article{Zelcer2014TheEU,
  title={The E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.},
  author={Noam Zelcer and Laura Jane Sharpe and Anke Loregger and Ika Kristiana and Emma C L Cook and Lisa Phan and Julian Stevenson and Andrew J Brown},
  journal={Molecular and cellular biology},
  year={2014},
  volume={34 7},
  pages={1262-70}
}
The mevalonate pathway is used by cells to produce sterol and nonsterol metabolites and is subject to tight metabolic regulation. We recently reported that squalene monooxygenase (SM), an enzyme controlling a rate-limiting step in cholesterol biosynthesis, is subject to cholesterol-dependent proteasomal degradation. However, the E3-ubiquitin (E3) ligase mediating this effect was not established. Using a candidate approach, we identify the E3 ligase membrane-associated RING finger 6 (MARCH6… CONTINUE READING

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