The E3 ubiquitin ligase CHIP selectively regulates mutant epidermal growth factor receptor by ubiquitination and degradation.

@article{Chung2016TheEU,
  title={The E3 ubiquitin ligase CHIP selectively regulates mutant epidermal growth factor receptor by ubiquitination and degradation.},
  author={Chaeuk Chung and Geon Wook Yoo and Tackhoon Kim and Dahye Lee and C Lee and Hye Rim Cha and Yeon Hee Park and Jae Young Moon and Sung Soo Jung and Ju Ock Kim and Jae Cheol Lee and Sun Young Kim and Hee Sun Park and Myoungrin Park and Dong Il Park and Dae-Sik Lim and Kang Won Jang and Jeong Eun Lee},
  journal={Biochemical and biophysical research communications},
  year={2016},
  volume={479 2},
  pages={152-158}
}
Somatic mutation in the tyrosine kinase domain of epidermal growth factor receptor (EGFR) is a decisive factor for the therapeutic response to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in lung adenocarcinoma. The stability of mutant EGFR is maintained by various regulators, including heat shock protein 90 (Hsp90). The C terminus of Hsc70-interacting… CONTINUE READING