The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.

@article{Wang2014TheEU,
  title={The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.},
  author={Qiang Wang and Xing Liu and Ye Cui and Yijun Tang and Wei Chen and Senlin Li and Huansha Yu and Youdong Pan and Chen Wang},
  journal={Immunity},
  year={2014},
  volume={41 6},
  pages={919-33}
}
Stimulator of interferon genes (STING, also known as MITA, ERIS, or MPYS) is essential for host immune responses triggered by microbial DNAs. However, the regulatory mechanisms underlying STING-mediated signaling are not fully understood. We report here that, upon cytoplasmic DNA stimulation, the endoplasmic reticulum (ER) protein AMFR was recruited to and interacted with STING in an insulin-induced gene 1 (INSIG1)-dependent manner. AMFR and INSIG1, an E3 ubiquitin ligase complex, then… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

The Regulation of cGAS

Virologica Sinica • 2018
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-4 of 4 references

NF-kappaB action by CITED2 in the nucleus. Journal of immunology

H. X. Shi, K. Yang, +5 authors C. Wang
Molecular and cellular biology • 2010
View 1 Excerpt

WDR5 is essential for assembly of the VISA-associated signaling complex and virus-triggered IRF3 and NF-kappaB activation.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 1 Excerpt

Similar Papers

Loading similar papers…