The E3 ligase CHIP mediates ubiquitination and degradation of mixed-lineage kinase 3.

@article{Blessing2014TheEL,
  title={The E3 ligase CHIP mediates ubiquitination and degradation of mixed-lineage kinase 3.},
  author={Natalya A. Blessing and April L Brockman and Deborah N. Chadee},
  journal={Molecular and cellular biology},
  year={2014},
  volume={34 16},
  pages={
          3132-43
        }
}
Mixed-lineage kinase 3 (MLK3) activates mitogen-activated protein kinase (MAPK) signaling pathways and has important functions in migration, invasion, proliferation, tumorigenesis, and apoptosis. We investigated the role of the E3 ligase carboxyl terminus of Hsc70-interacting protein (CHIP) in the regulation of MLK3 protein levels. We show that CHIP interacts with MLK3 and, together with the E2 ubiquitin-conjugating enzyme UbcH5 (UbcH5a, -b, -c, or -d), ubiquitinates MLK3 in vitro. CHIP or… CONTINUE READING

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