The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation

@inproceedings{Nakhaei2009TheEU,
  title={The E3 Ubiquitin Ligase Triad3A Negatively Regulates the RIG-I/MAVS Signaling Pathway by Targeting TRAF3 for Degradation},
  author={P. Nakhaei and Thibault Mespl{\`e}de and Mayra Solis and Qingnan Sun and Tiejun Zhao and Long Yang and Tsung-Hsien Chuang and Carl F Ware and Rongtuan Lin and John Hiscott},
  booktitle={PLoS pathogens},
  year={2009}
}
The primary role of the innate immune response is to limit the spread of infectious pathogens, with activation of Toll-like receptor (TLR) and RIG-like receptor (RLR) pathways resulting in a pro-inflammatory response required to combat infection. Limiting the activation of these signaling pathways is likewise essential to prevent tissue injury in the host. Triad3A is an E3 ubiquitin ligase that interacts with several components of TLR signaling and modulates TLR activity. In the present study… CONTINUE READING
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