The E3 Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance.

Abstract

Neuronal growth cone filopodia contain guidance receptors and contribute to axon guidance; however, the mechanism by which the guidance cue netrin increases filopodia density is unknown. Here, we demonstrate that TRIM9, an E3 ubiquitin ligase that localizes to filopodia tips and binds the netrin receptor DCC, interacts with and ubiquitinates the barbed-end… (More)
DOI: 10.1016/j.devcel.2015.11.022

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Cite this paper

@article{Menon2015TheEU, title={The E3 Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance.}, author={Shalini Menon and Nicholas Patrick Boyer and Cortney Chelise Winkle and Leslie Marie McClain and Christopher Carey Hanlin and Dharmendra H Pandey and Simon Rothenfusser and Anne Marion Taylor and Stephanie Lynn Gupton}, journal={Developmental cell}, year={2015}, volume={35 6}, pages={698-712} }