The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle.

@article{Clarke2007TheEL,
  title={The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle.},
  author={Brian A. Clarke and Doreen Drujan and Monte S Willis and Leon O. Murphy and Richard A. Corpina and Elena Burova and Sergey V. Rakhilin and Trevor Stitt and C. G. Patterson and Esther Latres and David J Glass},
  journal={Cell metabolism},
  year={2007},
  volume={6 5},
  pages={376-85}
}
Skeletal muscle atrophy occurs as a side effect of treatment with synthetic glucocorticoids such as dexamethasone (DEX) and is a hallmark of cachectic syndromes associated with increased cortisol levels. The E3 ubiquitin ligase MuRF1 (muscle RING finger protein 1) is transcriptionally upregulated by DEX treatment. Differentiated myotubes treated with DEX undergo depletion of myosin heavy chain protein (MYH), which physically associates with MuRF1. This loss of MYH can be blocked by inhibition… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS