The E2F transcriptional network: old acquaintances with new faces

  title={The E2F transcriptional network: old acquaintances with new faces},
  author={Desssislava K Dimova and Nicholas J. Dyson},
The E2 factor (E2F) family of transcription factors are downstream targets of the retinoblastoma protein. E2F factors have been known for several years to be important regulators of S-phase entry. Recent studies have improved our understanding of the molecular mechanisms of action used by this transcriptional network. In addition, they have given us an appreciation of the fact that E2F has functions that reach beyond G1/S control and impact cell proliferation in several different ways. The… CONTINUE READING
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