The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation.

@article{Lang2007TheED,
  title={The E295K DNA polymerase beta gastric cancer-associated variant interferes with base excision repair and induces cellular transformation.},
  author={Tieming Lang and Shibani Dalal and Anna Chikova and Daniel DiMaio and Joann Balazs Sweasy},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 15},
  pages={5587-96}
}
Approximately 30% of human tumors examined for mutations in polymerase beta (pol beta) appear to express pol beta variant proteins (D. Starcevic, S. Dalal, and J. B. Sweasy, Cell Cycle 3:998-1001, 2004). Many of these variants result from a single amino acid substitution. We have previously shown that the K289M and I260M colon and prostate cancer variants, respectively, induce cellular transformation most likely due to sequence-specific mutator activity (S. Dalal et al., Biochemistry 44:15664… CONTINUE READING
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