The E2-C Vihar Is Required for the Correct Spatiotemporal Proteolysis of Cyclin B and Itself Undergoes Cyclical Degradation

@article{Mth2004TheEV,
  title={The E2-C Vihar Is Required for the Correct Spatiotemporal Proteolysis of Cyclin B and Itself Undergoes Cyclical Degradation},
  author={Endre M{\'a}th{\'e} and Claudine Kraft and R{\'e}gis Giet and P{\'e}ter De{\'a}k and J. G. Peters and David M Glover},
  journal={Current Biology},
  year={2004},
  volume={14},
  pages={1723-1733}
}
BACKGROUND Proteolytic degradation of mitotic regulatory proteins first requires these targets to be ubiquitinated. This is regulated at the level of conjugation of ubiquitin to substrates by the anaphase-promoting complex/cyclosome (APC/C) ubiquitin-protein ligase. Substrate specificity and temporal activity of the APC/C has been thought to lie primarily with its two activators, Cdc20/Fizzy and Cdh1/Fizzy-related. RESULTS Here, we show that reduction in the E2 ubiquitin-conjugating enzyme… CONTINUE READING

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