The Dynamics of Platelet Activation during the Progression of Streptococcal Sepsis

  title={The Dynamics of Platelet Activation during the Progression of Streptococcal Sepsis},
  author={Sinead M. Hurley and Nataliya Lutay and B. I. Holmqvist and Oonagh Shannon},
  booktitle={PloS one},
Platelets contribute to inflammation however, the role of platelet activation during the pathophysiological response to invasive bacterial infection and sepsis is not clear. Herein, we have investigated platelet activation in a mouse model of invasive Streptococcus pyogenes infection at 5, 12, and 18 hours post infection and correlated this to parameters of infection. The platelet population in ex-vivo blood samples showed no increased integrin activation or surface presentation of CD62P… CONTINUE READING

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