The Dynamics of DNA Methylation Covariation Patterns in Carcinogenesis

@inproceedings{Teschendorff2014TheDO,
  title={The Dynamics of DNA Methylation Covariation Patterns in Carcinogenesis},
  author={Andrew E. Teschendorff and Xiaoping Liu and Helena Car{\'e}n and Steve M. Pollard and Stephan Beck and Martin Widschwendter and Luonan Chen},
  booktitle={PLoS Computational Biology},
  year={2014}
}
Recently it has been observed that cancer tissue is characterised by an increased variability in DNA methylation patterns. However, how the correlative patterns in genome-wide DNA methylation change during the carcinogenic progress has not yet been explored. Here we study genome-wide inter-CpG correlations in DNA methylation, in addition to single site variability, during cervical carcinogenesis. We demonstrate how the study of changes in DNA methylation covariation patterns across normal… CONTINUE READING
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