The Duration of Chlamydia muridarum Genital Tract Infection and Associated Chronic Pathological Changes Are Reduced in IL-17 Knockout Mice but Protection Is Not Increased Further by Immunization

@inproceedings{Andrew2013TheDO,
  title={The Duration of Chlamydia muridarum Genital Tract Infection and Associated Chronic Pathological Changes Are Reduced in IL-17 Knockout Mice but Protection Is Not Increased Further by Immunization},
  author={Dean W. Andrew and Melanie Cochrane and Justin H. Schripsema and Kyle H. Ramsey and Samantha J Dando and Connor P. O’Meara and Peter Timms and Kenneth W. Beagley},
  booktitle={PloS one},
  year={2013}
}
IL-17 is believed to be important for protection against extracellular pathogens, where clearance is dependent on neutrophil recruitment and local activation of epithelial cell defences. However, the role of IL-17 in protection against intracellular pathogens such as Chlamydia is less clear. We have compared (i) the course of natural genital tract C. muridarum infection, (ii) the development of oviduct pathology and (iii) the development of vaccine-induced immunity against infection in wild… CONTINUE READING
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