Corpus ID: 33415667

The Dunce cAMP phosphodiesterase PDE-4 negatively regulates G alpha(s)-dependent and G alpha(s)-independent cAMP pools in the Caenorhabditis elegans synaptic signaling network.

@article{Charlie2006TheDC,
  title={The Dunce cAMP phosphodiesterase PDE-4 negatively regulates G alpha(s)-dependent and G alpha(s)-independent cAMP pools in the Caenorhabditis elegans synaptic signaling network.},
  author={Nicole K. Charlie and Angela M Thomure and Michael A Schade and K. Miller},
  journal={Genetics},
  year={2006},
  volume={173 1},
  pages={
          111-30
        }
}
  • Nicole K. Charlie, Angela M Thomure, +1 author K. Miller
  • Published 2006
  • Medicine
  • Genetics
  • Forward genetic screens for mutations that rescue the paralysis of ric-8 (Synembryn) reduction-of-function mutations frequently reveal mutations that cause hyperactivation of one or more components of the G alpha(s) pathway. Here, we report that one of these mutations strongly reduces the function of the Dunce cAMP phosphodiesterase PDE-4 by disrupting a conserved active site residue. Loss of function and neural overexpression of PDE-4 have profound and opposite effects on locomotion rate, but… CONTINUE READING
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