The Duffy antigen receptor for chemokines, ACKR1,- 'Jeanne DARC' of benign neutropenia.

@article{Rappoport2019TheDA,
  title={The Duffy antigen receptor for chemokines, ACKR1,- 'Jeanne DARC' of benign neutropenia.},
  author={Naama Rappoport and Amos J Simon and Ninette Amariglio and Gideon Rechavi},
  journal={British journal of haematology},
  year={2019},
  volume={184 4},
  pages={
          497-507
        }
}
Benign neutropenia, observed in different ethnic groups, is the most common form of neutropenia worldwide. A specific single nucleotide polymorphism, rs2814778, located at the promoter of the ACKR1 (previously termed DARC) gene, which disrupts a binding site for the GATA1 erythroid transcription factor, resulting in a ACKR1-null phenotype, was found to serve as a predictor of low white blood cell and neutrophil counts in African-Americans and Yemenite Jews. Individuals with benign neutropenia… CONTINUE READING

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