The Duffy Antigen/Receptor for Chemokines (DARC) and Prostate-Cancer Risk among Jamaican Men

@article{Elson2010TheDA,
  title={The Duffy Antigen/Receptor for Chemokines (DARC) and Prostate-Cancer Risk among Jamaican Men},
  author={Joshua Knute Elson and Jennifer L Beebe-Dimmer and Hal L. Morgenstern and Mahdavi Chilkuri and John S Blanchard and Alex B. Lentsch},
  journal={Journal of Immigrant and Minority Health},
  year={2010},
  volume={13},
  pages={36-41}
}
As an evolutionary response to prevent malaria infection, most Africans do not express the Duffy Antigen/Receptor for Chemokines (DARC) on their red blood cells. Results from experimental studies suggest that DARC expression inhibits prostate-tumor growth. We tested the hypothesis that men of African descent who lack DARC expression are at increased risk of prostate cancer. A case–control study involving 81 age-matched pairs was conducted in Jamaica. Participants were interviewed to collect… CONTINUE READING
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