The Dual Phosphatase Activity of Synaptojanin1 Is Required for Both Efficient Synaptic Vesicle Endocytosis and Reavailability at Nerve Terminals

Abstract

Phosphoinositides have been implicated in synaptic vesicle recycling largely based on studies of enzymes that regulate phosphoinositide synthesis and hydrolysis. One such enzyme is synaptojanin1, a multifunctional protein conserved from yeast to humans, which contains two phosphoinositol phosphatase domains and a proline-rich domain. Genetic ablation of… (More)
DOI: 10.1016/j.neuron.2007.10.032

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@article{Mani2007TheDP, title={The Dual Phosphatase Activity of Synaptojanin1 Is Required for Both Efficient Synaptic Vesicle Endocytosis and Reavailability at Nerve Terminals}, author={Meera Mani and Sang Yoon Lee and Louise Lucast and Ottavio Cremona and Gilbert Di Paolo and Pietro De Camilli and Timothy A Ryan}, journal={Neuron}, year={2007}, volume={56}, pages={1004-1018} }