The Dual Impact of HIV-1 Infection and Aging on Naïve CD4+ T-Cells: Additive and Distinct Patterns of Impairment

  title={The Dual Impact of HIV-1 Infection and Aging on Na{\"i}ve CD4+ T-Cells: Additive and Distinct Patterns of Impairment},
  author={Tammy M. Rickabaugh and Ryan D. Kilpatrick and Lance E. Hultin and Patricia M. Hultin and Mary Ann Hausner and Catherine A. Sugar and Keri N. Althoff and Joseph B. Margolick and Charles R. Rinaldo and Roger Detels and John W Phair and Rita B. Effros and Beth D. Jamieson},
  booktitle={PloS one},
HIV-1-infected adults over the age of 50 years progress to AIDS more rapidly than adults in their twenties or thirties. In addition, HIV-1-infected individuals receiving antiretroviral therapy (ART) present with clinical diseases, such as various cancers and liver disease, more commonly seen in older uninfected adults. These observations suggest that HIV-1 infection in older persons can have detrimental immunological effects that are not completely reversed by ART. As naïve T-cells are… CONTINUE READING
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