The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF-κB To Dampen NF-κB–Stimulated Gene Transcription

  title={The Dual Function Cytokine IL-33 Interacts with the Transcription Factor NF-$\kappa$B To Dampen NF-$\kappa$B–Stimulated Gene Transcription},
  author={Shafaqat Ali and Antje Mohs and Meike Thomas and Jan Klare and Ralf Ross and Michael Lienhard Schmitz and Michael U. Martin},
  journal={The Journal of Immunology},
  pages={1609 - 1616}
Full-length IL-33 is a member of the IL-1 family of cytokines, which can act in an autocrine or paracrine manner by binding to the IL-33R on several different target cell types. In addition, IL-33 can act in an intracrine fashion by translocating to the nucleus, where it binds to the chromatin and modulates gene expression. In this article, we report that full-length IL-33, but not mature IL-33, interacts with the transcription factor NF-κB. This interaction occurs between the N-terminal part… 

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