The Dual Edema-Preventing Molecular Mechanism of the Crataegus Extract WS 1442 Can Be Assigned to Distinct Phytochemical Fractions.

  title={The Dual Edema-Preventing Molecular Mechanism of the Crataegus Extract WS 1442 Can Be Assigned to Distinct Phytochemical Fractions.},
  author={Simone Fuchs and Iris Bischoff and Elisabeth A. Willer and Jacqueline Br{\"a}utigam and Martin F. Bubik and Clemens A. J. Erdelmeier and Egon Koch and Maria Teresa Faleschini and Maria De Mieri and Milena Bauhart and Stefan Zahler and Andreas Hensel and Matthias Hamburger and Olivier Potterat and Robert F{\"u}rst},
  journal={Planta medica},
  volume={83 8},
The hawthorn (Crataegus spp.) extract WS 1442 is used against mild forms of chronic heart failure. This disease is associated with endothelial barrier dysfunction and edema formation. We have recently shown that WS 1442 protects against this dysfunction by a dual mechanism: it both promotes endothelial barrier integrity by activation of a barrier-enhancing pathway (cortactin activation) and inhibits endothelial hyperpermeability by blocking a barrier disruptive pathway (calcium signaling). In… 

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