The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.

@article{Justice1995TheDT,
  title={The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation.},
  author={Rendy Justice and Olav Zilian and Daniel F. Woods and Meenakshi Noll and Peter J. Bryant},
  journal={Genes & development},
  year={1995},
  volume={9 5},
  pages={534-46}
}
Homozygous loss of the warts (wts) gene of Drosophila, caused by mitotic recombination in somatic cells, leads to the formation of cell clones that are fragmented, rounded, and greatly overgrown compared with normal controls. Therefore, the gene is required for the control of the amount and direction of cell proliferation as well as for normal morphogenesis. The absence of wts function also results in apical hypertrophy of imaginal disc epithelial cells. Secretion of cuticle over and between… CONTINUE READING
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