The Drosophila takeout Gene Is a Novel Molecular Link between Circadian Rhythms and Feeding Behavior

@article{SarovBlat2000TheDT,
  title={The Drosophila takeout Gene Is a Novel Molecular Link between Circadian Rhythms and Feeding Behavior},
  author={Lea Sarov-Blat and W.Venus So and Li Liu and Michael Rosbash},
  journal={Cell},
  year={2000},
  volume={101},
  pages={647-656}
}
We report the characterization of a novel Drosophila circadian clock-regulated output gene, takeout (to). The to amino acid sequence shows similarity to two ligand binding proteins, including juvenile hormone binding protein. to mRNA is expressed in the head and the cardia, crop, and antennae-structures related to feeding. to expression is induced by starvation, which is blocked in all arrhythmic central clock mutants, suggesting a direct molecular link between the circadian clock and the… CONTINUE READING

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takeout, a novel Drosophila gene under circadian clock transcriptional regulation.

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