The Drosophila pumilio gene encodes two functional protein isoforms that play multiple roles in germline development, gonadogenesis, oogenesis and embryogenesis.

@article{Parisi1999TheDP,
  title={The Drosophila pumilio gene encodes two functional protein isoforms that play multiple roles in germline development, gonadogenesis, oogenesis and embryogenesis.},
  author={Michael J Parisi and Haifan Lin},
  journal={Genetics},
  year={1999},
  volume={153 1},
  pages={235-50}
}
The pumilio (pum) gene plays an essential role in embryonic patterning and germline stem cell (GSC) maintenance during oogenesis in Drosophila. Here we report on a phenotypic analysis using pum(ovarette) mutations, which reveals multiple functions of pum in primordial germ cell proliferation, larval ovary formation, GSC division, and subsequent oogenic processes, as well as in oviposition. Specifically, by inducing pum(-) GSC clones at the onset of oogenesis, we show that pum is directly… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-8 of 8 references

recombinase to produce female germline chimeras in Drosoph1996 Requirement for a noncoding RNA in Drosophila polarila

H. Lin
Genetics Science • 1998
View 3 Excerpts
Highly Influenced

Establishment of stem cell identity in the Drosophila germline.

Developmental dynamics : an official publication of the American Association of Anatomists • 1997

Spectrosomes and fusomes anchor

P. Rorth
1997

RNA regulatory elements

P. D. Zamore, J. R. Williamson
1991

Differing strategies for organizing anterior and back mRNA

M. Zaccai, H. D. Lipshitz
Development Nature • 1989

novel class of evolutionarily conserved genes defined by piwi are Determination of anterior polarity in Drosophila . Science 238 : essential for stem cell self renewal

C. A Nüsslein-Volhard, H. G. Frohnhofer, R. Lehmann
Genes Dev . • 1987

Dorsoventral patterning in Droin Drosophila

A. C. Verrotti, J. A. Schisa, M. E. Lieberfarb
Curr . Opin . Genet . Dev . Curr . Opin . Genet . Dev .

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