The Drosophila pericentrin-like protein is essential for cilia/flagella function, but appears to be dispensable for mitosis

@article{MartinezCampos2004TheDP,
  title={The Drosophila pericentrin-like protein is essential for cilia/flagella function, but appears to be dispensable for mitosis},
  author={Maruxa Martinez-Campos and Renata Basto and James Dillon Baker and Maurice J. Kernan and Jordan W Raff},
  journal={The Journal of Cell Biology},
  year={2004},
  volume={165},
  pages={673 - 683}
}
Centrosomes consist of a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Proteins that contain a Pericentrin/AKAP450 centrosomal targeting (PACT) domain have been implicated in recruiting several proteins to the PCM. We show that the only PACT domain protein in Drosophila (the Drosophila pericentrin-like protein [D-PLP]) is associated with both the centrioles and the PCM, and is essential for the efficient centrosomal recruitment of all six PCM components that we… CONTINUE READING

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