The Drosophila p21-activated kinase Mbt modulates DE-cadherin-mediated cell adhesion by phosphorylation of Armadillo.

@article{Menzel2008TheDP,
  title={The Drosophila p21-activated kinase Mbt modulates DE-cadherin-mediated cell adhesion by phosphorylation of Armadillo.},
  author={Nicolas Menzel and Juliane Melzer and Jens Waschke and Christof Lenz and Heike Wecklein and Guenter Lochnit and Detlev Drenckhahn and Thomas Raabe},
  journal={The Biochemical journal},
  year={2008},
  volume={416 2},
  pages={231-41}
}
Phosphorylation by tyrosine and serine/threonine kinases regulate the interactions between components of the cadherin-catenin cell-adhesion complex and thus can influence the dynamic modulation of cell adhesion under normal and disease conditions. Previous mutational analysis and localization experiments suggested an involvement of single members of the family of PAKs (p21-activated kinases) in the regulation of cadherin-mediated cell adhesion, but the molecular mechanism remained elusive. In… CONTINUE READING
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