The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog.

@article{Gorfinkiel2005TheDO,
  title={The Drosophila ortholog of the human Wnt inhibitor factor Shifted controls the diffusion of lipid-modified Hedgehog.},
  author={Nicole Gorfinkiel and Javier Cote Sierra and Ainhoa I Callejo and Carmen Ib{\'a}{\~n}ez and Isabel Guerrero},
  journal={Developmental cell},
  year={2005},
  volume={8 2},
  pages={
          241-53
        }
}
The Hedgehog (Hh) family of morphogenetic proteins has important instructional roles in metazoan development and human diseases. Lipid modified Hh is able to migrate to and program cells far away from its site of production despite being associated with membranes. To investigate the Hh spreading mechanism, we characterized Shifted (Shf) as a component in the Drosophila Hh pathway. We show that Shf is the ortholog of the human Wnt inhibitory factor (WIF), a secreted antagonist of the Wingless… CONTINUE READING
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