The Drosophila nucleosome remodeling factor NURF is required for Ecdysteroid signaling and metamorphosis.

@article{Badenhorst2005TheDN,
  title={The Drosophila nucleosome remodeling factor NURF is required for Ecdysteroid signaling and metamorphosis.},
  author={Paul Badenhorst and Hua Xiao and Lucy Cherbas and So Yeon Kwon and Matt Voas and Ilaria Rebay and Peter Cherbas and Carl H. Wu},
  journal={Genes & development},
  year={2005},
  volume={19 21},
  pages={2540-5}
}
Drosophila NURF is an ISWI-containing ATP-dependent chromatin remodeling complex that regulates transcription by catalyzing nucleosome sliding. To determine in vivo gene targets of NURF, we performed whole genome expression analysis on mutants lacking the NURF-specific subunit NURF301. Strikingly, a large set of ecdysone-responsive targets is included among several hundred NURF-regulated genes. Null Nurf301 mutants do not undergo larval to pupal metamorphosis, and also enhance dominant-negative… CONTINUE READING