The Drosophila miR-310 Cluster Negatively Regulates Synaptic Strength at the Neuromuscular Junction

@article{Tsurudome2010TheDM,
  title={The Drosophila miR-310 Cluster Negatively Regulates Synaptic Strength at the Neuromuscular Junction},
  author={Kazuya Tsurudome and Karen H Tsang and Edward H Liao and Robin Ball and Jay Penney and Jr-Shiuan Yang and Fatima Elazzouzi and Tao He and Athar H Chishti and Greg Lnenicka and Eric C. Lai and A Pejmun Haghighi},
  journal={Neuron},
  year={2010},
  volume={68},
  pages={879-893}
}
Emerging data implicate microRNAs (miRNAs) in the regulation of synaptic structure and function, but we know little about their role in the regulation of neurotransmission in presynaptic neurons. Here, we demonstrate that the miR-310-313 cluster is required for normal synaptic transmission at the Drosophila larval neuromuscular junction. Loss of miR-310-313 cluster leads to a significant enhancement of neurotransmitter release, which can be rescued with temporally restricted expression of mir… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Homeostatic plasticity at the Drosophila neuromuscular junction.

Neuropharmacology • 2014
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 65 references

Maturation of active zone assembly by Drosophila Bruchpilot

The Journal of cell biology • 2009
View 4 Excerpts
Highly Influenced

Reconstruct: A free editor for serial section microscopy

J. C. Fiala
J. Microsc. 218, 52–61. • 2005
View 2 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…