The Drosophila melanogaster Genetic Reference Panel

Abstract

A major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics.

DOI: 10.1038/nature10811

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@inproceedings{Mackay2012TheDM, title={The Drosophila melanogaster Genetic Reference Panel}, author={Trudy F C Mackay and Stephen M Richards and Eric A. Stone and Antonio Barbadilla and Julien F. Ayroles and Dianhui Zhu and S{\`o}nia Casillas and Yi Han and Michael M. Magwire and Julie M. Cridland and Mark F Richardson and Robert R H Anholt and Maite G Barr{\'o}n and Crystal Bess and Kerstin Petra Blankenburg and Mary Anna Carbone and David Castellano and Lesley S. Chaboub and Laura H. Duncan and Zeke Harris and M. Javaid and Joy Christina Jayaseelan and Shalini N. Jhangiani and Katherine W Jordan and Fremiet Lara and F. V. Lawrence and Sandra L. Lee and Pablo Librado and Raquel S Linheiro and Richard F . Lyman and Aaron J. Mackey and Mala Munidasa and Donna M. Muzny and Lynne V. Nazareth and Irene F. Newsham and Lora Perales and L . Pu and Carson Qu and Miquel R{\`a}mia and Jeffrey G. Reid and Stephanie M Rollmann and Julio Rozas and Nehad Saada and Lavanya Turlapati and Kim Worley and Yuanqing Wu and Akihiko H. Yamamoto and Yimin Zhu and Casey M. Bergman and Kevin R. Thornton and David Mittelman and Richard A. Gibbs}, booktitle={Nature}, year={2012} }