The Drosophila kinesin light chain. Primary structure and interaction with kinesin heavy chain.

  title={The Drosophila kinesin light chain. Primary structure and interaction with kinesin heavy chain.},
  author={A. Gauger and Lawrence S B Goldstein},
  journal={The Journal of biological chemistry},
  volume={268 18},
Kinesin light chain (KLC) complexes with the kinesin heavy chain (KHC) to form native kinesin. Proposed functions of KLC include coupling of cargo to KHC or modulation of KHC ATPase activity. In this paper we use the KHC tail, which binds specifically to KLC in blot overlays, as a probe to clone a cDNA encoding KLC from a Drosophila expression library. The identified clone encodes a protein with 70% amino acid identity to rat KLC. Drosophila KLC is predicted to form an alpha-helical coiled-coil… Expand
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The characterization of the KLC3 gene suggests that it carries out a unique and specialized role in spermatids, and may be involved in cargo binding and regulation of kinesin activity. Expand
Association of Kinesin Light Chain with Outer Dense Fibers in a Microtubule-independent Fashion*
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Defective Kinesin Heavy Chain Behavior in Mouse Kinesin Light Chain Mutants
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A specific light chain of kinesin associates with mitochondria in cultured cells.
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The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline
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Unique and Shared Functions of Kinesin Light Chain and Milton in Drosophila Oogenesis and Axonal Transport
The data suggest that Klc is working as a critical factor in these Kinesin-1 driven transport events, including a previously undescribed role in mitochondrial transport. Expand
The ribosome receptor, p180, interacts with kinesin heavy chain, KIF5B.
A yeast two-hybrid assay was employed to identify additional binding partners of the kinesin heavy chain isoform KIF5B and identified the ribosome receptor, p180, as a Kif5B-binding protein. Expand
Two Kinesin Light Chain Genes in Mice
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