The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels.

  title={The Drosophila insulin/IGF receptor controls growth and size by modulating PtdInsP(3) levels.},
  author={Sean Oldham and Hugo Stocker and Muriel Laffargue and Franz Wittwer and Matthias P Wymann and Ernst Hafen},
  volume={129 17},
Understanding the control of size is of fundamental biological and clinical importance. Insulin/IGF signaling during development controls growth and size, possibly by coordinating the activities of the Ras and PI 3-kinase signaling pathways. We show that in Drosophila mutating the consensus binding site for the Ras pathway adaptor Drk/Grb2 in Chico/IRS does not interfere with growth whereas mutating the binding sites of the PI 3-kinase adaptor p60 completely abrogates Chico function… CONTINUE READING
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