The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning.

@article{Mohan2007TheDI,
  title={The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning.},
  author={Man Mohan and Marek Bartkuhn and Martin Herold and Angela Philippen and Nina Heinl and Imke Bardenhagen and Joerg Leers and Robert White and Renate Renkawitz-Pohl and Harald Saumweber and Rainer Renkawitz},
  journal={The EMBO journal},
  year={2007},
  volume={26 19},
  pages={4203-14}
}
Insulator sequences guide the function of distantly located enhancer elements to the appropriate target genes by blocking inappropriate interactions. In Drosophila, five different insulator binding proteins have been identified, Zw5, BEAF-32, GAGA factor, Su(Hw) and dCTCF. Only dCTCF has a known conserved counterpart in vertebrates. Here we find that the… CONTINUE READING