The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision.

@article{Su1999TheDH,
  title={The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision.},
  author={Ming-Yen Thomas Su and Makio Fujioka and Toshiyasu Goto and Rolf Bodmer},
  journal={Development},
  year={1999},
  volume={126 14},
  pages={3241-51}
}
A series of inductive signals are necessary to subdivide the mesoderm in order to allow the formation of the progenitor cells of the heart. Mesoderm-endogenous transcription factors, such as those encoded by twist and tinman, seem to cooperate with these signals to confer correct context and competence for a cardiac cell fate. Additional factors are likely to be required for the appropriate specification of individual cell types within the forming heart. Similar to tinman, the zinc finger- and… CONTINUE READING
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