The Drosophila dosage compensation complex binds to polytene chromosomes independently of developmental changes in transcription.

@article{Kotlikova2006TheDD,
  title={The Drosophila dosage compensation complex binds to polytene chromosomes independently of developmental changes in transcription.},
  author={Irina V. Kotlikova and Olga V. Demakova and Valery F. Semeshin and Viktor V. Shloma and Lidiya V. Boldyreva and Mitzi I. Kuroda and Igor F. Zhimulev},
  journal={Genetics},
  year={2006},
  volume={172 2},
  pages={963-74}
}
In Drosophila, the dosage compensation complex (DCC) mediates upregulation of transcription from the single male X chromosome. Despite coating the polytene male X, the DCC pattern looks discontinuous and probably reflects DCC dynamic associations with genes active at a given moment of development in a salivary gland. To test this hypothesis, we compared binding patterns of the DCC and of the elongating form of RNA polymerase II (PolIIo). We found that, unlike PolIIo, the DCC demonstrates a… CONTINUE READING

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