The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process.

@article{Muro2006TheDC,
  title={The Drosophila caspase Ice is important for many apoptotic cell deaths and for spermatid individualization, a nonapoptotic process.},
  author={Israel Muro and Deborah L. Berry and Jun R. Huh and Chun Hong Chen and Haixia Huang and Soon Ji Yoo and Ming Guo and Eric H. Baehrecke and Bruce A. Hay},
  journal={Development},
  year={2006},
  volume={133 17},
  pages={3305-15}
}
Caspase family proteases play important roles in the regulation of apoptotic cell death. Initiator caspases are activated in response to death stimuli, and they transduce and amplify these signals by cleaving and thereby activating effector caspases. In Drosophila, the initiator caspase Nc (previously Dronc) cleaves and activates two short-prodomain caspases, Dcp-1 and Ice (previously Drice), suggesting these as candidate effectors of Nc killing activity. dcp-1-null mutants are healthy and… CONTINUE READING
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