The Drosophila bunched gene is a homologue of the growth factor stimulated mammalian TSC-22 sequence and is required during oogenesis

@article{Dobens1997TheDB,
  title={The Drosophila bunched gene is a homologue of the growth factor stimulated mammalian TSC-22 sequence and is required during oogenesis},
  author={Leonard L Dobens and Tien Hsu and Vern Twombly and William M. Gelbart and Laurel A. Raftery and F. C. Kafatos},
  journal={Mechanisms of Development},
  year={1997},
  volume={65},
  pages={197-208}
}
A Drosophila melanogaster sequence homologous to the mammalian growth factor-stimulated TSC-22 gene was isolated in an enhancer trap screen for genes expressed in anterodorsal follicle cells during oogenesis. This sequence includes a 225 aa residue open reading frame that encompasses a leucine zipper motif immediately preceded by a highly conserved region (TSC box), similarly located but distinct from the basic domain of bZIP proteins. The gene encoding this sequence, bunched (bun), has been… CONTINUE READING
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