The Drosophila alcohol dehydrogenase gene may have evolved independently of the functionally homologous medfly, olive fly, and flesh fly genes.

@article{Brogna2001TheDA,
  title={The Drosophila alcohol dehydrogenase gene may have evolved independently of the functionally homologous medfly, olive fly, and flesh fly genes.},
  author={Saverio Brogna and Panayiotis V. Benos and Giuliano Gasperi and Charalambos Savakis},
  journal={Molecular biology and evolution},
  year={2001},
  volume={18 3},
  pages={322-9}
}
cDNAs for alcohol dehydrogenase (ADH) isozymes were cloned and sequenced from two tephritid fruit flies, the medfly Ceratitis capitata and the olive fly Bactrocera oleae. Because of the high sequence divergence compared with the Drosophila sequences, the medfly cDNAs were cloned using sequence information from the purified proteins, and the olive fly cDNAs were cloned by functional complementation in yeast. The medfly peptide sequences are about 83% identical to each other, and the… CONTINUE READING