The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy

@inproceedings{Chittaranjan2015TheDT,
  title={The Drosophila TIPE family member Sigmar interacts with the Ste20-like kinase Misshapen and modulates JNK signaling, cytoskeletal remodeling and autophagy},
  author={Suganthi Chittaranjan and Jing Xu and Michael A. Kuzyk and Harpreet K. Dullat and James Wilton and L Devorkin and Chandra B Lebovitz and Gregg B Morin and Marco A. Marra and Sharon M Gorski},
  booktitle={Biology open},
  year={2015}
}
TNFAIP8 and other mammalian TIPE family proteins have attracted increased interest due to their associations with disease-related processes including oncogenic transformation, metastasis, and inflammation. The molecular and cellular functions of TIPE family proteins are still not well understood. Here we report the molecular and genetic characterization of the Drosophila TNFAIP8 homolog, CG4091/sigmar. Previous gene expression studies revealed dynamic expression of sigmar in larval salivary… CONTINUE READING
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