The Drosophila Sin3 gene encodes a widely distributed transcription factor essential for embryonic viability

@article{Pennetta1998TheDS,
  title={The Drosophila Sin3 gene encodes a widely distributed transcription factor essential for embryonic viability},
  author={Giuseppa Pennetta and Daniel Pauli},
  journal={Development Genes and Evolution},
  year={1998},
  volume={208},
  pages={531-536}
}
 Expression of many mammalian genes is activated by the binding of heterodimers of the Myc and Max proteins to specific DNA sequences called the E-boxes. Transcription of the same genes is repressed upon binding to the same sequences of complexes composed of Max, Mad/Mxi1, the co-repressors Sin3 and N-CoR, and the histone deacetylase Rpd3. Max-Mad/Mxi1 heterodimers, which bind to E-boxes in absence of co-repressors, do not inhibit gene expression simply by competition with Myc-Max heterodimers… CONTINUE READING

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A complex containing NCoR , mSin 3 and histone deacetylase mediates transcriptional repression

  • T Heinzel, RM Lavinsky, +11 authors MG Rosenfeld
  • Nature
  • 1997

Role for NCoR and histone deacetylase in Sin 3mediated transcriptional repression

  • L Alland, R Muhle, J Potes, L Chin, N Schreiber-Agus, RA DePinho
  • Nature
  • 1997

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