The Drosophila Pipsqueak protein defines a new family of helix-turn-helix DNA-binding proteins

@article{Siegmund2002TheDP,
  title={The Drosophila Pipsqueak protein defines a new family of helix-turn-helix DNA-binding proteins},
  author={Thomas Siegmund and Michael Lehmann},
  journal={Development Genes and Evolution},
  year={2002},
  volume={212},
  pages={152-157}
}
Many prokaryotic and eukaryotic DNA-binding proteins use a helix-turn-helix (HTH) structure for DNA recognition. Here we describe a new family of eukaryotic HTH proteins, the Pipsqueak (Psq) family, which includes proteins from fungi, sea urchins, nematodes, insects, and vertebrates. Three subgroups of the Psq family can be distinguished. Like the HTH proteins of the prokaryotic resolvase family, members of the CENP-B/transposase subgroup catalyze site-specific recombination reactions. This… CONTINUE READING

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