The Drosophila Orphan Nuclear Receptor DHR38 Mediates an Atypical Ecdysteroid Signaling Pathway

@article{Baker2003TheDO,
  title={The Drosophila Orphan Nuclear Receptor DHR38 Mediates an Atypical Ecdysteroid Signaling Pathway},
  author={Keith D. Baker and Lisa M. Shewchuk and Tatiana Kozlova and Makoto Makishima and Annie M. Hassell and Bruce B Wisely and Justin A. Caravella and Millard H. Lambert and Jeffrey L. Reinking and Henry M Krause and Carl S Thummel and Timothy M Willson and David J Mangelsdorf},
  journal={Cell},
  year={2003},
  volume={113},
  pages={731-742}
}
Ecdysteroid pulses trigger the major developmental transitions during the Drosophila life cycle. These hormonal responses are thought to be mediated by the ecdysteroid receptor (EcR) and its heterodimeric partner Ultraspiracle (USP). We provide evidence for a second ecdysteroid signaling pathway mediated by DHR38, the Drosophila ortholog of the mammalian NGFI-B subfamily of orphan nuclear receptors. DHR38 also heterodimerizes with USP, and this complex responds to a distinct class of… CONTINUE READING