The Drosophila NURF remodelling and the ATAC histone acetylase complexes functionally interact and are required for global chromosome organization.

@article{Carr2008TheDN,
  title={The Drosophila NURF remodelling and the ATAC histone acetylase complexes functionally interact and are required for global chromosome organization.},
  author={Cl{\'e}ment Carr{\'e} and Anita Ciurciu and Orb{\'a}n Komonyi and Caroline Jacquier and Delphine Fagegaltier and Josette Pidoux and H{\'e}rv{\'e} Tricoire and L{\'a}szl{\'o} Tora and I M Boros and Christophe Antoniewski},
  journal={EMBO reports},
  year={2008},
  volume={9 2},
  pages={187-92}
}
Drosophila Gcn5 is the catalytic subunit of the SAGA and ATAC histone acetylase complexes. Here, we show that mutations in Gcn5 and the ATAC component Ada2a induce a decondensation of the male X chromosome, similar to that induced by mutations in the Iswi and Nurf301 subunits of the NURF nucleosome remodelling complex. Genetic studies as well as transcript profiling analysis indicate that ATAC and NURF regulate overlapping sets of target genes during development. In addition, we find that Ada2a… CONTINUE READING

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