The Drosophila LEM-domain protein MAN1 antagonizes BMP signaling at the neuromuscular junction and the wing crossveins.

@article{Wagner2010TheDL,
  title={The Drosophila LEM-domain protein MAN1 antagonizes BMP signaling at the neuromuscular junction and the wing crossveins.},
  author={Nicole Wagner and Annika Weyhersm{\"u}ller and Anna Blauth and Tamara Schuhmann and Manfred Heckmann and Georg Krohne and Christos Samakovlis},
  journal={Developmental biology},
  year={2010},
  volume={339 1},
  pages={1-13}
}
BMP signaling responses are refined by distinct secreted and intracellular antagonists in different cellular and temporal contexts. Here, we show that the nuclear LEM-domain protein MAN1 is a tissue-specific antagonist of BMP signaling in Drosophila. MAN1 contains two potential Mad-binding sites. We generated MAN1DeltaC mutants, harbouring a MAN1 protein that lacks part of the C-terminus including the RNA recognition motif, a putative Mad-binding domain. MAN1DeltaC mutants show wing crossvein… CONTINUE READING
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function : Tolloid - related processes Sog in order to help specify the posterior crossvein in the Drosophila wing

  • O. Shimmi, A. Ralston, S. S. Blair, M. B. O'Connor
  • 2005
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