The Drosophila Gene abnormal spindle Encodes a Novel Microtubule-associated Protein That Associates with the Polar Regions of the Mitotic Spindle

@article{Saunders1997TheDG,
  title={The Drosophila Gene abnormal spindle Encodes a Novel Microtubule-associated Protein That Associates with the Polar Regions of the Mitotic Spindle},
  author={Robert D. C. Saunders and Maria do Carmo Avides and Thomas P Howard and Cayetano Gonzalez and David M Glover},
  journal={The Journal of Cell Biology},
  year={1997},
  volume={137},
  pages={881 - 890}
}
abnormal spindle, a gene required for normal spindle structure and function in Drosophila melanogaster, lies immediately adjacent the gene tolloid at 96A/B. It encodes a 220-kD polypeptide with a predicted pI of 10.8. The recessive mutant allele asp1 directs the synthesis of a COOH terminally truncated or internally deleted peptide of approximately 124 kD. Wild-type Asp protein copurifies with microtubules and is not released by salt concentrations known to dissociate most other microtubule… CONTINUE READING

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