The Drosophila Fragile X Gene Negatively Regulates Neuronal Elaboration and Synaptic Differentiation

  title={The Drosophila Fragile X Gene Negatively Regulates Neuronal Elaboration and Synaptic Differentiation},
  author={Luyuan Pan and Yong qun Zhang and Elvin A Woodruff and Kendal Broadie},
  journal={Current Biology},
Fragile X Syndrome (FraX) is the most common form of inherited mental retardation. The disease is caused by the silencing of the fragile X mental retardation 1 (fmr1) gene, which encodes the RNA binding translational regulator FMRP . In FraX patients and fmr1 knockout mice, loss of FMRP causes denser and morphologically altered postsynaptic dendritic spines . Previously, we established a Drosophila FraX model and showed that dFMRP acts as a negative translational regulator of Futsch/MAP1B and… CONTINUE READING
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