The Drosophila F Box Protein Archipelago Regulates dMyc Protein Levels In Vivo

  title={The Drosophila F Box Protein Archipelago Regulates dMyc Protein Levels In Vivo},
  author={Kenneth H. Moberg and Ashim Mukherjee and Alexey Veraksa and S. Artavanis-Tsakonas and Iswar K Hariharan},
  journal={Current Biology},
BACKGROUND The Myc oncoprotein is an important regulator of cellular growth in metazoan organisms. Its levels and activity are tightly controlled in vivo by a variety of mechanisms. In normal cells, Myc protein is rapidly degraded, but the mechanism of its degradation is not well understood. RESULTS Here we present genetic and biochemical evidence that Archipelago (Ago), the F box component of an SCF-ubiquitin ligase and the Drosophila ortholog of a human tumor suppressor, negatively… CONTINUE READING

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