The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball, a locus essential for embryonic development.

@article{Schejter1989TheDE,
  title={The Drosophila EGF receptor homolog (DER) gene is allelic to faint little ball, a locus essential for embryonic development.},
  author={Eyal D. Schejter and Ben-Zion Shilo},
  journal={Cell},
  year={1989},
  volume={56 6},
  pages={1093-104}
}
Recessive lethal mutations in the genetic locus of the Drosophila EGF receptor homolog (DER) were isolated. Identification of mutations in the gene is based on assays of DER protein autophosphorylation activity. Most DER alleles show little or no in vivo autophosphorylation. The ability to monitor these activities in vivo and in vitro offers a preliminary insight into the functional defects in the different mutant proteins. The identification of the DER locus was also confirmed by partial… CONTINUE READING

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