The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling

  title={The Drosophila Duox maturation factor is a key component of a positive feedback loop that sustains regeneration signaling},
  author={Sumbul Jawed Khan and Syeda Nayab Fatima Abidi and Andrea Skinner and Yuan Tian and Rachel K. Smith-Bolton},
  journal={PLoS Genetics},
Regenerating tissue must initiate the signaling that drives regenerative growth, and sustain that signaling long enough for regeneration to complete. How these key signals are sustained is unclear. To gain a comprehensive view of the changes in gene expression that occur during regeneration, we performed whole-genome mRNAseq of actively regenerating tissue from damaged Drosophila wing imaginal discs. We used genetic tools to ablate the wing primordium to induce regeneration, and carried out… 

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