The Drosophila DOCK family protein sponge is involved in differentiation of R7 photoreceptor cells.

@article{Eguchi2013TheDD,
  title={The Drosophila DOCK family protein sponge is involved in differentiation of R7 photoreceptor cells.},
  author={Koichi Eguchi and Yasuhide Yoshioka and Hideki Yoshida and Kazushige Morishita and Seiji Miyata and Hiroshi Hiai and Masamitsu Yamaguchi},
  journal={Experimental cell research},
  year={2013},
  volume={319 14},
  pages={2179-95}
}
The Drosophila sponge (spg)/CG31048 gene belongs to the dedicator of cytokinesis (DOCK) family genes that are conserved in a wide variety of species. DOCK family members are known as DOCK1-DOCK11 in mammals. Although DOCK1 and DOCK2 involve neurite elongation and immunocyte differentiation, respectively, the functions of other DOCK family members are not fully understood. Spg is a Drosophila homolog of mammalian DOCK3 and DOCK4. Specific knockdown of spg by the GMR-GAL4 driver in eye imaginal… CONTINUE READING