The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan

@article{Yamazaki2007TheDD,
  title={The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan},
  author={D. Yamazaki and Junjiro Horiuchi and Yasuko Nakagami and Shintaro Nagano and Takuya Tamura and Minoru Saitoe},
  journal={Nature Neuroscience},
  year={2007},
  volume={10},
  pages={478-484}
}
The study of age-related memory impairment (AMI) has been hindered by a lack of AMI-specific mutants. In a screen for such mutants in Drosophila melanogaster, we found that heterozygous mutations of DCO (DCO/+), which encodes the major catalytic subunit of cAMP-dependent protein kinase (PKA), delay AMI more than twofold without affecting lifespan or memory at early ages. AMI is restored when a DCO transgene is expressed in mushroom bodies, structures important for olfactory memory formation… CONTINUE READING