The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan

@article{Yamazaki2007TheDD,
  title={The Drosophila DCO mutation suppresses age-related memory impairment without affecting lifespan},
  author={D. Yamazaki and J. Horiuchi and Yasuko Nakagami and S. Nagano and T. Tamura and M. Saitoe},
  journal={Nature Neuroscience},
  year={2007},
  volume={10},
  pages={478-484}
}
  • D. Yamazaki, J. Horiuchi, +3 authors M. Saitoe
  • Published 2007
  • Medicine, Biology
  • Nature Neuroscience
  • The study of age-related memory impairment (AMI) has been hindered by a lack of AMI-specific mutants. In a screen for such mutants in Drosophila melanogaster, we found that heterozygous mutations of DCO (DCO/+), which encodes the major catalytic subunit of cAMP-dependent protein kinase (PKA), delay AMI more than twofold without affecting lifespan or memory at early ages. AMI is restored when a DCO transgene is expressed in mushroom bodies, structures important for olfactory memory formation… CONTINUE READING

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